Peptide Sequences | Protein1
| Affinity2 HLA-A*1101 | Elicit IFN-γ3 in | Immunogenicity4 in mice |
---|
 |  |  |
Seropositive human
|
Seronegative human
| Â |
---|
KSFKDILPK | SAG1224-232
| 54 | + | - | + |
AMLTAFFLR | GRA6164-172
| 3.6 | + | - | + |
RSFKDLLKK | GRA7134-142
| 14 | + | - | - |
STFWPCLLR | SAG2C13-21
| 10 | + | - | + |
SSAYVFSVK | SPA250-258
| 10 | + | - | + |
AVVSLLRLLK | SPA89-98
| 34 | + | - | + |
- 1Peptides derived from these proteins and the position within the proteins
- 2Binding affinity was performed by MHC binding assay.
- 3PBMC from four T. gondii-seropositive HLA-A03 supertype persons and four seronegative persons were stimulated with peptides, the T cell that produce IFN-γ were tested by ELISpot assay.
- 4Splenic T cell were isolated from HLA-A*03 supertype(which includes the HLA-A*1101 haplotype) mice 10 to 14 days after peptide immunization and tested for their ability to generate IFN-γ in response to peptide.