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Immunome Research

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  1. Content type: Research

    Toxoplasmosis causes loss of life, cognitive and motor function, and sight. A vaccine is greatly needed to prevent this disease. The purpose of this study was to use an immmunosense approach to develop a found...

    Authors: Hua Cong, Ernest J Mui, William H Witola, John Sidney, Jeff Alexander, Alessandro Sette, Ajesh Maewal and Rima McLeod

    Citation: Immunome Research 2010 6:12

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  2. Content type: Research

    The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell...

    Authors: Duccio Cavalieri, Damariz Rivero, Luca Beltrame, Sonja I Buschow, Enrica Calura, Lisa Rizzetto, Sandra Gessani, Maria C Gauzzi, Walter Reith, Andreas Baur, Roberto Bonaiuti, Marco Brandizi, Carlotta De Filippo, Ugo D'Oro, Sorin Draghici, Isabelle Dunand-Sauthier…

    Citation: Immunome Research 2010 6:10

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  3. Content type: Research

    Macrophages represent the front lines of our immune system; they recognize and engulf pathogens or foreign particles thus initiating the immune response. Imaging macrophages presents unique challenges, as most...

    Authors: Robert J Milewski, Yutaro Kumagai, Katsumasa Fujita, Daron M Standley and Nicholas I Smith

    Citation: Immunome Research 2010 6:11

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  4. Content type: Research

    Binding of peptides to Major Histocompatibility class II (MHC-II) molecules play a central role in governing responses of the adaptive immune system. MHC-II molecules sample peptides from the extracellular spa...

    Authors: Morten Nielsen, Sune Justesen, Ole Lund, Claus Lundegaard and Søren Buus

    Citation: Immunome Research 2010 6:9

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  5. Content type: Research

    The last years have seen a renaissance of the vaccine area, driven by clinical needs in infectious diseases but also chronic diseases such as cancer and autoimmune disorders. Equally important are technologica...

    Authors: Johannes Söllner, Andreas Heinzel, Georg Summer, Raul Fechete, Laszlo Stipkovits, Susan Szathmary and Bernd Mayer

    Citation: Immunome Research 2010 6(Suppl 2):S7

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    This article is part of a Supplement: Volume 6 Supplement 2

  6. Content type: Review

    Viruses are fast evolving pathogens that continuously adapt to the highly variable environments they live and reproduce in. Strategies devoted to inhibit virus replication and to control their spread among hos...

    Authors: Samuel Ojosnegros and Niko Beerenwinkel

    Citation: Immunome Research 2010 6(Suppl 2):S5

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    This article is part of a Supplement: Volume 6 Supplement 2

  7. Content type: Review

    Sequence based T-cell epitope predictions have improved immensely in the last decade. From predictions of peptide binding to major histocompatibility complex molecules with moderate accuracy, limited allele co...

    Authors: Claus Lundegaard, Ilka Hoof, Ole Lund and Morten Nielsen

    Citation: Immunome Research 2010 6(Suppl 2):S3

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  8. Content type: Review

    Immunoinformatics is an emergent branch of informatics science that long ago pullulated from the tree of knowledge that is bioinformatics. It is a discipline which applies informatic techniques to problems of ...

    Authors: Darren R Flower, Isabel K Macdonald, Kamna Ramakrishnan, Matthew N Davies and Irini A Doytchinova

    Citation: Immunome Research 2010 6(Suppl 2):S1

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    This article is part of a Supplement: Volume 6 Supplement 2

  9. Content type: Review

    To properly characterize protective polyclonal antibody responses, it is necessary to examine epitope specificity. Most antibody epitopes are conformational in nature and, thus, cannot be identified using synt...

    Authors: Galina F Denisova, Dimitri A Denisov and Jonathan L Bramson

    Citation: Immunome Research 2010 6(Suppl 2):S6

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  10. Content type: Review

    Atomistic Molecular Dynamics provides powerful and flexible tools for the prediction and analysis of molecular and macromolecular systems. Specifically, it provides a means by which we can measure theoreticall...

    Authors: Darren R Flower, Kanchan Phadwal, Isabel K Macdonald, Peter V Coveney, Matthew N Davies and Shunzhou Wan

    Citation: Immunome Research 2010 6(Suppl 2):S4

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    This article is part of a Supplement: Volume 6 Supplement 2

  11. Content type: Methodology

    Operation of the immune system is multivariate. Reduction of the dimensionality is essential to facilitate understanding of this complex biological system. One multi-dimensional facet of the immune system is t...

    Authors: Robert D Bremel and E Jane Homan

    Citation: Immunome Research 2010 6:7

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  12. Content type: Proceedings

    Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis, one of the commonest zoonotic diseases found worldwide in humans and a variety of animal species. While several animal v...

    Authors: Yongqun He and Zuoshuang Xiang

    Citation: Immunome Research 2010 6(Suppl 1):S5

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    This article is part of a Supplement: Volume 6 Supplement 1

  13. Content type: Proceedings

    Recent advances in Immunology highlighted the importance of local properties on the overall progression of HIV infection. In particular, the gastrointestinal tract is seen as a key area during early infection,...

    Authors: Dimitri Perrin, Heather J Ruskin and Martin Crane

    Citation: Immunome Research 2010 6(Suppl 1):S3

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    This article is part of a Supplement: Volume 6 Supplement 1

  14. Content type: Proceedings

    The enrichment and importance of some aromatic residues, such as Tyr and Trp, have been widely noticed at the binding interfaces of antibodies from many experimental and statistical results, some of which were...

    Authors: Di Wu, Jing Sun, Tianlei Xu, Shuning Wang, Guoqing Li, Yixue Li and Zhiwei Cao

    Citation: Immunome Research 2010 6(Suppl 1):S1

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    This article is part of a Supplement: Volume 6 Supplement 1

  15. Content type: Proceedings

    Identification of antigenic peptide epitopes is an essential prerequisite in T cell-based molecular vaccine design. Computational (sequence-based and structure-based) methods are inexpensive and efficient comp...

    Authors: Javed Mohammed Khan and Shoba Ranganathan

    Citation: Immunome Research 2010 6(Suppl 1):S2

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    This article is part of a Supplement: Volume 6 Supplement 1

  16. Content type: Proceedings

    Selective peptide transport by the transporter associated with antigen processing (TAP) represents one of the main candidate mechanisms that may regulate the presentation of antigenic peptides to HLA class I m...

    Authors: Tze Hau Lam, Hiroshi Mamitsuka, Ee Chee Ren and Joo Chuan Tong

    Citation: Immunome Research 2010 6(Suppl 1):S6

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    This article is part of a Supplement: Volume 6 Supplement 1

  17. Content type: Proceedings

    Clonal expansion of B lymphocytes coupled with somatic mutation and antigen selection allow the mammalian humoral immune system to generate highly specific immunoglobulins (IG) or antibodies against invading b...

    Authors: Zhiliang Chen, Andrew M Collins, Yan Wang and Bruno A Gaëta

    Citation: Immunome Research 2010 6(Suppl 1):S4

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  18. Content type: Research

    Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Are...

    Authors: Maya F Kotturi, Jason Botten, Matt Maybeno, John Sidney, Jean Glenn, Huynh-Hoa Bui, Carla Oseroff, Shane Crotty, Bjoern Peters, Howard Grey, Daniel M Altmann, Michael J Buchmeier and Alessandro Sette

    Citation: Immunome Research 2010 6:4

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  19. Content type: Research

    Gene coregulation across a population is an important aspect of the considerable variability of the human immune response to virus infection. Methodology to investigate it must rely on a number of ingredients ...

    Authors: German Nudelman, Yongchao Ge, Jianzhong Hu, Madhu Kumar, Jeremy Seto, Jamie L Duke, Steven H Kleinstein, Fernand Hayot, Stuart C Sealfon and James G Wetmur

    Citation: Immunome Research 2010 6:2

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