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  1. Toxoplasmosis causes loss of life, cognitive and motor function, and sight. A vaccine is greatly needed to prevent this disease. The purpose of this study was to use an immmunosense approach to develop a found...

    Authors: Hua Cong, Ernest J Mui, William H Witola, John Sidney, Jeff Alexander, Alessandro Sette, Ajesh Maewal and Rima McLeod

    Citation: Immunome Research 2010 6:12

    Content type: Research

    Published on:

  2. Macrophages represent the front lines of our immune system; they recognize and engulf pathogens or foreign particles thus initiating the immune response. Imaging macrophages presents unique challenges, as most...

    Authors: Robert J Milewski, Yutaro Kumagai, Katsumasa Fujita, Daron M Standley and Nicholas I Smith

    Citation: Immunome Research 2010 6:11

    Content type: Research

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  3. The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell...

    Authors: Duccio Cavalieri, Damariz Rivero, Luca Beltrame, Sonja I Buschow, Enrica Calura, Lisa Rizzetto, Sandra Gessani, Maria C Gauzzi, Walter Reith, Andreas Baur, Roberto Bonaiuti, Marco Brandizi, Carlotta De Filippo, Ugo D'Oro, Sorin Draghici, Isabelle Dunand-Sauthier…

    Citation: Immunome Research 2010 6:10

    Content type: Research

    Published on:

  4. Binding of peptides to Major Histocompatibility class II (MHC-II) molecules play a central role in governing responses of the adaptive immune system. MHC-II molecules sample peptides from the extracellular spa...

    Authors: Morten Nielsen, Sune Justesen, Ole Lund, Claus Lundegaard and Søren Buus

    Citation: Immunome Research 2010 6:9

    Content type: Research

    Published on:

  5. The last years have seen a renaissance of the vaccine area, driven by clinical needs in infectious diseases but also chronic diseases such as cancer and autoimmune disorders. Equally important are technologica...

    Authors: Johannes Söllner, Andreas Heinzel, Georg Summer, Raul Fechete, Laszlo Stipkovits, Susan Szathmary and Bernd Mayer

    Citation: Immunome Research 2010 6(Suppl 2):S7

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  6. To properly characterize protective polyclonal antibody responses, it is necessary to examine epitope specificity. Most antibody epitopes are conformational in nature and, thus, cannot be identified using synt...

    Authors: Galina F Denisova, Dimitri A Denisov and Jonathan L Bramson

    Citation: Immunome Research 2010 6(Suppl 2):S6

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  7. Viruses are fast evolving pathogens that continuously adapt to the highly variable environments they live and reproduce in. Strategies devoted to inhibit virus replication and to control their spread among hos...

    Authors: Samuel Ojosnegros and Niko Beerenwinkel

    Citation: Immunome Research 2010 6(Suppl 2):S5

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  8. Atomistic Molecular Dynamics provides powerful and flexible tools for the prediction and analysis of molecular and macromolecular systems. Specifically, it provides a means by which we can measure theoreticall...

    Authors: Darren R Flower, Kanchan Phadwal, Isabel K Macdonald, Peter V Coveney, Matthew N Davies and Shunzhou Wan

    Citation: Immunome Research 2010 6(Suppl 2):S4

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  9. Sequence based T-cell epitope predictions have improved immensely in the last decade. From predictions of peptide binding to major histocompatibility complex molecules with moderate accuracy, limited allele co...

    Authors: Claus Lundegaard, Ilka Hoof, Ole Lund and Morten Nielsen

    Citation: Immunome Research 2010 6(Suppl 2):S3

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  10. Immunoinformatics is an emergent branch of informatics science that long ago pullulated from the tree of knowledge that is bioinformatics. It is a discipline which applies informatic techniques to problems of ...

    Authors: Darren R Flower, Isabel K Macdonald, Kamna Ramakrishnan, Matthew N Davies and Irini A Doytchinova

    Citation: Immunome Research 2010 6(Suppl 2):S1

    Content type: Review

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 2

  11. Operation of the immune system is multivariate. Reduction of the dimensionality is essential to facilitate understanding of this complex biological system. One multi-dimensional facet of the immune system is t...

    Authors: Robert D Bremel and E Jane Homan

    Citation: Immunome Research 2010 6:7

    Content type: Methodology

    Published on:

  12. Selective peptide transport by the transporter associated with antigen processing (TAP) represents one of the main candidate mechanisms that may regulate the presentation of antigenic peptides to HLA class I m...

    Authors: Tze Hau Lam, Hiroshi Mamitsuka, Ee Chee Ren and Joo Chuan Tong

    Citation: Immunome Research 2010 6(Suppl 1):S6

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  13. Brucella spp. are Gram-negative, facultative intracellular bacteria that cause brucellosis, one of the commonest zoonotic diseases found worldwide in humans and a variety of animal species. While several animal v...

    Authors: Yongqun He and Zuoshuang Xiang

    Citation: Immunome Research 2010 6(Suppl 1):S5

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  14. Clonal expansion of B lymphocytes coupled with somatic mutation and antigen selection allow the mammalian humoral immune system to generate highly specific immunoglobulins (IG) or antibodies against invading b...

    Authors: Zhiliang Chen, Andrew M Collins, Yan Wang and Bruno A Gaëta

    Citation: Immunome Research 2010 6(Suppl 1):S4

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  15. Recent advances in Immunology highlighted the importance of local properties on the overall progression of HIV infection. In particular, the gastrointestinal tract is seen as a key area during early infection,...

    Authors: Dimitri Perrin, Heather J Ruskin and Martin Crane

    Citation: Immunome Research 2010 6(Suppl 1):S3

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  16. Identification of antigenic peptide epitopes is an essential prerequisite in T cell-based molecular vaccine design. Computational (sequence-based and structure-based) methods are inexpensive and efficient comp...

    Authors: Javed Mohammed Khan and Shoba Ranganathan

    Citation: Immunome Research 2010 6(Suppl 1):S2

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  17. The enrichment and importance of some aromatic residues, such as Tyr and Trp, have been widely noticed at the binding interfaces of antibodies from many experimental and statistical results, some of which were...

    Authors: Di Wu, Jing Sun, Tianlei Xu, Shuning Wang, Guoqing Li, Yixue Li and Zhiwei Cao

    Citation: Immunome Research 2010 6(Suppl 1):S1

    Content type: Proceedings

    Published on:

    This article is part of a Supplement: Volume 6 Supplement 1

  18. Several arenaviruses cause severe hemorrhagic fever and aseptic meningitis in humans for which no licensed vaccines are available. A major obstacle for vaccine development is pathogen heterogeneity within the Are...

    Authors: Maya F Kotturi, Jason Botten, Matt Maybeno, John Sidney, Jean Glenn, Huynh-Hoa Bui, Carla Oseroff, Shane Crotty, Bjoern Peters, Howard Grey, Daniel M Altmann, Michael J Buchmeier and Alessandro Sette

    Citation: Immunome Research 2010 6:4

    Content type: Research

    Published on:

  19. Gene coregulation across a population is an important aspect of the considerable variability of the human immune response to virus infection. Methodology to investigate it must rely on a number of ingredients ...

    Authors: German Nudelman, Yongchao Ge, Jianzhong Hu, Madhu Kumar, Jeremy Seto, Jamie L Duke, Steven H Kleinstein, Fernand Hayot, Stuart C Sealfon and James G Wetmur

    Citation: Immunome Research 2010 6:2

    Content type: Research

    Published on:

  20. Biology is moving fast toward the virtuous circle of other disciplines: from data to quantitative modeling and back to data. Models are usually developed by mathematicians, physicists, and computer scientists ...

    Authors: Francesco Pappalardo, Marie-Paule Lefranc, Pier-Luigi Lollini and Santo Motta

    Citation: Immunome Research 2010 6:1

    Content type: Research

    Published on:

  21. Dendritic cells (DCs) are the sentinels of the mammalian immune system, characterized by a complex maturation process driven by pathogen detection. Although multiple studies have described the analysis of acti...

    Authors: Maurizio Ceppi, Giovanna Clavarino, Evelina Gatti, Enrico K Schmidt, Aude de Gassart, Derek Blankenship, Gerald Ogola, Jacques Banchereau, Damien Chaussabel and Philippe Pierre

    Citation: Immunome Research 2009 5:5

    Content type: Research

    Published on:

  22. Using a combined in silico approach, we investigated the glycosylation of T cell epitopes and autoantigens. The present systems biology analysis was made possible by currently available databases (representing fu...

    Authors: Tamás G Szabó, Robin Palotai, Péter Antal, Itay Tokatly, László Tóthfalusi, Ole Lund, György Nagy, András Falus and Edit I Buzás

    Citation: Immunome Research 2009 5:4

    Content type: Research

    Published on:

  23. Previous studies have defined vaccinia virus (VACV)-derived T cell epitopes in VACV-infected human leukocyte antigen-A*0201 (HLA-A2.1) transgenic (Tg) mice and A2.1-positive human Dryvax vaccinees. A total of ...

    Authors: Maya F Kotturi, Erika Assarsson, Bjoern Peters, Howard Grey, Carla Oseroff, Valerie Pasquetto and Alessandro Sette

    Citation: Immunome Research 2009 5:3

    Content type: Research

    Published on:

  24. Molecules of the class II major histocompability complex (MHC-II) specifically bind and present exogenously derived peptide epitopes to CD4+ T helper cells. The extreme polymorphism of the MHC-II hampers the c...

    Authors: Sune Justesen, Mikkel Harndahl, Kasper Lamberth, Lise-Lotte B Nielsen and Søren Buus

    Citation: Immunome Research 2009 5:2

    Content type: Research

    Published on:

  25. A wealth of information on clinical trials has been provided by publicly accessible online registries. Information technology and data exchange standards enable rapid extraction, summarization, and visualizati...

    Authors: Xiaohong Cao, Karen B Maloney and Vladimir Brusic

    Citation: Immunome Research 2008 4:7

    Content type: Research

    Published on:

  26. Monocytes and macrophages express an extensive repertoire of G Protein-Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we performed a systematic micro-array analysis of GPCR ex...

    Authors: Jane E Lattin, Kate Schroder, Andrew I Su, John R Walker, Jie Zhang, Tim Wiltshire, Kaoru Saijo, Christopher K Glass, David A Hume, Stuart Kellie and Matthew J Sweet

    Citation: Immunome Research 2008 4:5

    Content type: Research

    Published on:

  27. It has been previously shown that combinatorial peptide libraries are a useful tool to characterize the binding specificity of class I MHC molecules. Compared to other methodologies, such as pool sequencing or...

    Authors: John Sidney, Erika Assarsson, Carrie Moore, Sandy Ngo, Clemencia Pinilla, Alessandro Sette and Bjoern Peters

    Citation: Immunome Research 2008 4:2

    Content type: Research

    Published on:

  28. The application of peptide based diagnostics and therapeutics mimicking part of protein antigen is experiencing renewed interest. So far selection and design rationale for such peptides is usually driven by T-...

    Authors: Johannes Sollner, Rainer Grohmann, Ronald Rapberger, Paul Perco, Arno Lukas and Bernd Mayer

    Citation: Immunome Research 2008 4:1

    Content type: Research

    Published on:

  29. Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, remains a leading cause of infectious disease morbidity and mortality, and is responsible for more than 2 million deaths a year. Reports about ext...

    Authors: Martin J Blythe, Qing Zhang, Kerrie Vaughan, Romulo de Castro Jr, Nima Salimi, Huynh-Hoa Bui, David M Lewinsohn, Joel D Ernst, Bjoern Peters and Alessandro Sette

    Citation: Immunome Research 2007 3:10

    Content type: Research

    Published on:

  30. Understanding the interaction between viral proteins and neutralizing antibodies at atomic resolution is hindered by a lack of experimentally solved complexes. Progress in computational docking has led to the ...

    Authors: Brett A McKinney, Nicole L Kallewaard, James E Crowe Jr and Jens Meiler

    Citation: Immunome Research 2007 3:8

    Content type: Research

    Published on:

  31. HLA-C locus products are poorly understood in part due to their low expression at the cell surface. Recent data indicate that these molecules serve as major restriction elements for human immunodeficiency viru...

    Authors: Joo Chuan Tong, Zong Hong Zhang, J Thomas August, Vladimir Brusic, Tin Wee Tan and Shoba Ranganathan

    Citation: Immunome Research 2007 3:7

    Content type: Research

    Published on:

  32. The ImmunoDeficiency Resource (IDR) is a knowledge base for the integration of the clinical, biochemical, genetic, genomic, proteomic, structural, and computational data of primary immunodeficiencies. The need...

    Authors: Crina Samarghitean, Jouni Väliaho and Mauno Vihinen

    Citation: Immunome Research 2007 3:6

    Content type: Database

    Published on:

  33. Peptides derived from endogenous antigens can bind to MHC class I molecules. Those which bind with high affinity can invoke a CD8+ immune response, resulting in the destruction of infected cells. Much work in imm...

    Authors: Brett Trost, Mik Bickis and Anthony Kusalik

    Citation: Immunome Research 2007 3:5

    Content type: Research

    Published on:

  34. Structural information about epitopes, particularly the three-dimensional (3D) structures of antigens in complex with immune receptors, presents a valuable source of data for immunology. This information is av...

    Authors: John E Beaver, Philip E Bourne and Julia V Ponomarenko

    Citation: Immunome Research 2007 3:3

    Content type: Software

    Published on:

  35. Immunity against the bovine protozoan parasite Theileria parva has previously been shown to be mediated through lysis of parasite-infected cells by MHC class I restricted CD8+ cytotoxic T lymphocytes. It is hypot...

    Authors: Simon P Graham, Yoshikazu Honda, Roger Pellé, Duncan M Mwangi, E Jane Glew, Etienne P de Villiers, Trushar Shah, Richard Bishop, Pierre van der Bruggen, Vishvanath Nene and Evans LN Taracha

    Citation: Immunome Research 2007 3:2

    Content type: Research

    Published on:

  36. Arenaviruses are a family of rodent-borne viruses that cause several hemorrhagic fevers. These diseases can be devastating and are often lethal. Herein, to aid in the design and development of diagnostics, tre...

    Authors: Huynh-Hoa Bui, Jason Botten, Nicolas Fusseder, Valerie Pasquetto, Bianca Mothe, Michael J Buchmeier and Alessandro Sette

    Citation: Immunome Research 2007 3:1

    Content type: Database

    Published on:

  37. Cytokines are small proteins that regulate immunity in vertebrate species. Marsupial and eutherian mammals last shared a common ancestor more than 180 million years ago, so it is not surprising that attempts t...

    Authors: Emily SW Wong, Lauren J Young, Anthony T Papenfuss and Katherine Belov

    Citation: Immunome Research 2006 2:4

    Content type: Research

    Published on:

  38. The transporter associated with antigen processing (TAP) is a critical component of the major histocompatibility complex (MHC) class I antigen processing and presentation pathway. TAP transports antigenic pept...

    Authors: Guang Lan Zhang, Nikolai Petrovsky, Chee Keong Kwoh, J Thomas August and Vladimir Brusic

    Citation: Immunome Research 2006 2:3

    Content type: Software

    Published on:

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