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Table 1 Sequence and structural similarity between the eight (DRB1*0402, *0404, *0406, *1401, *1404, *1405, DQB1*0202, and *0503) MHC structural models and their corresponding template structures (1D5Z: DRB1*0401, 1S9V: DQB1*0201, 1UVQ: DQB1*0602). Positives represent a measure of sequence similarity, accounting for identical and conservatively substituted residues. Root mean square deviations (RMSD) values in Å are shown for the Cα atoms of both MHC chains and for the residues comprising the different peptide-binding pockets.

From: Modeling the bound conformation of Pemphigus Vulgaris-associated peptides to MHC Class II DR and DQ Alleles

Allele

Template

Sequence Identity

Positives

Cα RMSD (Å)

    

α & β chains

Pockets

     

P1

P4

P6

P7

P9

DRB1*0402

1D5Z

97.9%

99.0%

0.35

0.12

0.06

0.07

0.10

0.09

DRB1*0404

1D5Z

99.0%

99.5%

0.31

0.15

0.10

0.06

0.07

0.18

DRB1*0406

1D5Z

97.9%

98.4%

0.32

0.11

0.15

0.07

0.11

0.22

DRB1*1401

1D5Z

94.1%

97.3%

0.25

0.11

0.09

0.02

0.09

0.18

DRB1*1404

1D5Z

85.8%

89.5%

0.29

0.12

0.10

0.02

0.06

0.22

DRB1*1405

1D5Z

81.0%

83.2%

0.24

0.11

0.07

0.02

0.08

0.07

DQB1*0202

1S9V

98.0%

99.0%

0.57

0.16

0.09

0.04

0.15

0.05

DQB1*0503

1UVQ

93.0%

96.0%

0.39

0.03

0.07

0.01

0.10

0.06