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Table 1 Comparison of putative opossum and known human cytokine sequences. Opossum IFN-α genes were compared with 13 human IFN-α genes.

From: In silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals

Identity

Number of exons in open reading frame

Number of amino acids

% amino acid identity*

Cytokines

opossum

human

opossum

human

 

Interleukin 2

4

4

144

153

41.8

Interleukin 4

4

4

138

153

43.3

Interleukin 5

4

4

137

134

53.0

Interleukin 6

5

5

221

212

36.3

Interleukin 10

5

5

173

178

59.5

Interleukin 12A

7

7

231

253

52.2

Interleukin 13

4

4

122

146

36.7

Interleukin 19

6

6

188

215

58.0

Interleukin 20

6

5

154

176

59.7

Interleukin 21

5

5

163

162

46.5

Interleukin 22

4

5

150

179

40.0

Interleukin 24

6

6

220

206

43.7

Interleukin 26

5

5

201

171

55.9

Interferon γ

4

4

167

166

47.0

Type 1 Interferons

     

IFN-α (seven genes)

1

1

183

188–9 (range)

33–42 (range)

IFN-β

1

1

184

187

43.2

IFN-κ

1

1

156

207

51.3

Cytokine receptors

     

Common cytokine receptor gamma chain (IL-2Rγ)

8

8

349

367

54.9

Interferon-γ receptor 2

6

7

269

344

49.6

T cell surface receptors

     

CD4

9

9

485

458

45.6

CD8

6

6

349

235

37.7

  1. * compared with human sequence