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Table 2 Individual tool A ROC values and sensitivity data for HLA-B*3501 using binders and nonbinders from the community binding resource.

From: Strength in numbers: achieving greater accuracy in MHC-I binding prediction by combining the results from multiple prediction tools

Tool

A ROC

0.99 Specificity

0.95 Specificity

  

Rank

Sensitivity

Threshold

Rank

Sensitivity

Threshold

ARB Matrix

0.849

1

0.242

12.890

1

0.422

296.090

Bimas

0.808

7

0.047

60.000

8

0.166

24.000

NetMHC 2.0 Matrix

0.789

2

0.137

32.386

2

0.336

28.404

HLA Ligand

0.786

8

0.043

162.000

4

0.237

145.000

Rankpep

0.769

5

0.071

124.000

3

0.256

107.000

Logistic Regression

0.764

11

0.024

0.655

11

0.123

0.259

SVMHC SYFPEITHI

0.742

3

0.118

0.680

6

0.204

0.420

SVMHC MHCPEP

0.733

8

0.043

1.560

6

0.204

1.140

MHCPred (position only)

0.692

6

0.057

140.600

9

0.156

210.860

MHCPred (interactions)

0.683

4

0.090

52.240

5

0.209

179.470

Predep

0.587

10

0.038

-6.020

10

0.128

-5.090

  1. For details, see the caption for Table 1.