Strength in numbers: achieving greater accuracy in MHC-I binding prediction by combining the results from multiple prediction tools

Table 5 Performance of the heuristic-based method on all four datasets

Specificity	HLA-A*0201 (comm)	HLA-B*3501 (comm)	H-2Kd (comm)	HLA-A*0201 (lit)
0.99	0.404	0.313	0.467	0.271
0.95	0.618	0.393	0.617	0.475

The sensitivity of the HBM is shown at 0.99 specificity and 0.95 specificity for all four of the datasets used in this study. All values were obtained using a value of 0.99 for the individual tool specificity parameter. The abbreviation "comm" refers to peptides derived from the community binding database, while "lit" refers to peptides gathered from the literature.