Figure 5

Proposed high-resolution structure of antibody-antigen complex. Best-scoring high-resolution (RV6-26-VP6) complex. The heavy chain of the RV6-26 Fab is shaded green and the light chain blue. Interface VP6 residues on chain B within 5Å of the active antibody residues are shaded orange. The active Fab residues that most affect binding affinity upon back-mutation have side chains shaded red. The CDR2 loop, which contains half of the active residues, is also shaded red.