Of mice and humans: how good are HLA transgenic mice as a model of human immune responses?

Immunome Research

Table 1 Summary of overlap between A2.1-restricted VACV T cell epitope recognition in HLA Tg mice and human systems

Epitope	Sequence	Original Identification	Reference	Average Net SFC/10⁶ Cells
				Tg Mice	Human
A6L_172–180	ILSDENYLL	Human	[9]	-	106
A26L_177–186	YLYTEYFLFL	Human	[9]	-	164
A36R_1–9	MMLVPLITV	Human	[9]	75	49
A55R_78–86	YIYGIPLSL	Human	[9]	-	94
D3R_342–350	FLVIAINAM	Human	[9]	-	195
E2L_249–257	KIDYYIPYV	Human	[9]	87	192
E9L_107–115	FLNISWFYI	Human	[9]	48	132
F12L_286–295	NLFDIPLLTV	Human	[9]	132	252
F12L_404–412	FLTSVINRV	Human	[9]	90	73
I4L_720–728	SMHFYGWSL	Human	[9]	-	102
N2L_93–101	YVNAILYQI	Human	[9]	-	563
O1L_247–255	GLNDYLHSV	Human	[9]	104	77
C7L_74–82	KVDDTFYYV	Human + Tg mice	[5, 9, 14, 15, 18]	100	178
G5R_18–26	ILDDNLYKV	Human + Tg mice	[5, 9, 14]	141	271
A6L_6–14	VLYDEFVTI	Tg mice	[5]	126	-
A14L_51–59	FILGIIITV	Tg mice	[5]	844	60
A17L_61–70	RTLLGLILFV	Tg mice	[5]	279	-
A17L_81–90	ILMIFISSFL	Tg mice	[5]	773	42
A17L_138–146	QIFNIISYI	Tg mice	[13]	231	-
A46R_142–150	GLFDFVNFV	Tg mice	[5]	202	-
B6R_108–116	LMYDIINSV	Tg mice	[5]	222	-
B14R_327–335	HVDGKILFV	Tg mice	[5]	137	-
D12L_251–259	RVYEALYYV	Tg mice	[5]	112	63
F11L_196–204	FLIVSLCPT	Tg mice	[5]	150	-
G7L_250–258	YLPEVISTI	Tg mice	[5]	86	-
H3L_184–192	SLSAYIIRV	Tg mice	[5, 16]	213	-
I1L_211–219	RLYDYFTRV	Tg mice	[5]	179	115
M1L_374–383	IIIPFIAYFV	Tg mice	[5]	840	91