Table 1 Top "biological functions" of mRNA molecules affected by translation regulation in LPS-activated moDCs
From: Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS
Category (nr. of molecules) | Biological Function | p-value | Molecules (gene symbols) |
|---|---|---|---|
Protein Synthesis (26) | biosynthesis of proteins and translation regulation | 1.73E-04 | ADAMTS5, CASP9, EEF2, EIF2A, EIF4A2, EIF4B, NCK1, PLAU, PSMC2, RBM3, RPL3, RPL5, RPL7, RPL13, RPL14, RPL15, RPL26, RPL31, RPL37, RPL38, RPL9, RPS11, SERPINB1, SRGN, UBC, UBE2K |
RNA Post-Transcriptional Modification (12) | modification of mRNA | 8.67E-03 | CDC5L, CPSF1, DBR1, EIF4A2, EIF4B, GRSF1, HNRNPR, CPSF1, GRSF1, MAPKAPK2, ZFP36, QARS |
Amino Acid Metabolism (11) | catabolism of L-tryptophan and dephosphorylation of amino acids | 8.57E-08 | CD80, IL6, INDO, KMO, KYNU, DUSP2, DUSP3, PPM1A, PPM1F, PPP1CB, PTPN6 |
Cell Morphology (10) | transmembrane potential of mitochondria | 1.26E-03 | AP2A2, BNIP3, CASP9, CFLAR, IL6, MAPK9, MOAP1, NFE2L2, PTPN6, SRGN |
Immune Cell Trafficking (8) | emigration of leukocytes | 2.08E-03 | CD44, CXCL3, CXCR4, CYTIP, GFI1, LDLR, PLAU |
Cancer (7) | tumorigenesis of intestinal tissue | 2.64E-03 | APC, MLH1, IFI16, SMARCA2, HSPA1A, IFI16, IGFBP4 |
Nucleic Acid Metabolism (5) | metabolism of nucleic acid component | 6.15E-04 | ATIC, MTAP, OAS1, OAS2, REXO2 |
Cell-mediated Immune Response (4) | secretion of cytokine | 3.60E-03 | CADM1, LCP2, SRGN, GFI1 |
Antigen Presentation (2) | antigen peptide transporter | 8.84E-03 | TAP1, TAP2 |
Small molecule biochemistry (1) | activation by LPS | 4.21E-02 | LY96 (MD2) |