Figure 8

Immunoglobulin_Cancer cell as an instance of the "Molecule_Cell_Interaction" concept in models related to immunotherapy, as defined in CMM. This instance is shown as IG_CC in Fig. 2. The interaction between the immunoglobulin and the antigen (Ag), on the surface of the cancer cell (in CMM, Ag is represented by p185), is the starting event that leads to effector interactions: (i) binding, at the cell level, of natural killer (NK) to cancer cell ("Cell_Cell_Interaction") and, at the molecule level, of the Fc receptor (FcR), on the surface of NK, to the IG that has recognized Ag on the cancer cell surface ("Molecule_Molecule_Interaction") and (ii) binding of the complement (Cpt) to the IG that has recognized Ag on the cancer cell surface ("Molecule_Molecule_Interaction"). These interactions by NK or complement lead to the killing of the cancer cell by 'antibody dependent cell cytotoxicity' or ADCC or 'complement dependent cytotoxicity' (CDC), respectively (IMGT Education > IMGT Lexique, ADCC and CDC, http://www.imgt.org).