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Figure 4 | Immunome Research

Figure 4

From: DC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells

Figure 4

Pathway analysis on microarray data on DCs stimulated with R848 and LPS using DC-ATLAS pathways. (A) Section of clustering of PEF and score using Euclidean distance using support trees on DCs stimulated with R848 and LPS for different periods of time: 3, 6, 12 and 24 hours. Colored spots indicate significant up- (red) or down- (green) regulation. The colors of the dendrogram indicate the percentages of the tree support (significance), from 50% (pink) to 100% (black). The pathways are named as name of receptor_module_adaptor-TF involved. "s", "t" and "o" indicated sensing, transduction and outcome module, respectively. The total matrix used for clustering is available as Additional file 5. (B) Interpolation of DEGs of DCs in response to 3 hours LPS stimulation, the specific agonist of TLR4 signaling, with the gene lists representative of elements participating in TLR7/TLR8 pathways and representative of elements composing TLR4 pathway (in the Venn diagram indicated as TLR7, TLR8 and TLR4, respectively). (C) SBGN representation of the TLR4 pathway highlighting gene regulation upon 3 hours-stimulation with LPS. Red indicates up-regulation while green signifies down-regulation. (D) SBGN representation of the TLR4 pathway highlighting gene regulation at 6 hours. The full figures are available as Additional file 6 Figure S3 and Additional file 7 Figure S4, respectively.

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