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Table 2 Number of HLA-DRB1, DRB3, DRB4, and DRB5 molecules bound by the arenavirus-specific CD4+ T cell epitopes.

From: Polyfunctional CD4+ T cell responses to a set of pathogenic arenaviruses provide broad population coverage

Epitopea

No. DRB1 molecules boundb

No. DRB3/4/5 molecules boundc

Total No. DR molecules bound

GTOV GPC131-145

4

1

5

GTOV L181-195

3

1

4

GTOV L391-405

9

1

10

GTOV L1826-1840

8

2

10

GTOV NP166-180

8

1

9

GTOV NP191-205

8

2

10

GTOV NP236-250

10

1

11

GTOV NP541-555

9

2

11

JUNV GPC46-60

6

1

7

JUNV L381-395

10

3

13

JUNV L391-405

8

1

9

JUNV L411-425

6

1

7

JUNV L1491-1505

8

2

10

JUNV L1711-1725

8

1

9

LASV GPC236-250

7

2

9

LASV GPC241-255

7

1

8

LASV GPC476-490

1

1

2

LCMV GPC421-435

6

2

8

LCMV L256-270

3

1

4

LCMV L946-960

8

3

11

LCMV NP6-20

7

2

9

LCMV NP521-535

5

2

7

MACV GPC96-110

3

1

4

MACV GPC251-265

8

2

10

MACV GPC446-460

2

1

3

MACV L391-405

7

1

8

MACV L636-650

10

3

13

MACV L866-880

7

2

9

MACV L1491-1505

9

3

12

MACV L1711-1725

8

1

9

MACV NP191-205

8

2

10

MACV Z21-35

8

2

10

SABV GPC26-40

7

2

9

SABV GPC436-450

5

1

6

SABV GPC441-455

7

1

8

WWAV GPC46-60

5

1

6

WWAV GPC386-400

6

2

8

  1. a Peptide position within the GPC, L, NP, or Z protein of prototypic strains of GTOV, JUNV, LASV, LCMV, MACV, SABV, and WWAV.
  2. b Each epitope was tested for binding to 14 common HLA molecules within the DR supertype. The number of HLA molecules bound corresponds to the epitope having an IC50 ≤ 200 nM to the specific HLA molecule.
  3. c The number of DRB3*0101, DRB4*0101, and DRB5*0101 molecules bound by the arenavirus epitopes with an IC50 ≤ 200 nM.
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Immunome Research

ISSN: 1745-7580