|
Epitopea
|
No. DRB1 molecules boundb
|
No. DRB3/4/5 molecules boundc
|
Total No. DR molecules bound
|
|---|
|
GTOV GPC131-145
|
4
|
1
|
5
|
|
GTOV L181-195
|
3
|
1
|
4
|
|
GTOV L391-405
|
9
|
1
|
10
|
|
GTOV L1826-1840
|
8
|
2
|
10
|
|
GTOV NP166-180
|
8
|
1
|
9
|
|
GTOV NP191-205
|
8
|
2
|
10
|
|
GTOV NP236-250
|
10
|
1
|
11
|
|
GTOV NP541-555
|
9
|
2
|
11
|
|
JUNV GPC46-60
|
6
|
1
|
7
|
|
JUNV L381-395
|
10
|
3
|
13
|
|
JUNV L391-405
|
8
|
1
|
9
|
|
JUNV L411-425
|
6
|
1
|
7
|
|
JUNV L1491-1505
|
8
|
2
|
10
|
|
JUNV L1711-1725
|
8
|
1
|
9
|
|
LASV GPC236-250
|
7
|
2
|
9
|
|
LASV GPC241-255
|
7
|
1
|
8
|
|
LASV GPC476-490
|
1
|
1
|
2
|
|
LCMV GPC421-435
|
6
|
2
|
8
|
|
LCMV L256-270
|
3
|
1
|
4
|
|
LCMV L946-960
|
8
|
3
|
11
|
|
LCMV NP6-20
|
7
|
2
|
9
|
|
LCMV NP521-535
|
5
|
2
|
7
|
|
MACV GPC96-110
|
3
|
1
|
4
|
|
MACV GPC251-265
|
8
|
2
|
10
|
|
MACV GPC446-460
|
2
|
1
|
3
|
|
MACV L391-405
|
7
|
1
|
8
|
|
MACV L636-650
|
10
|
3
|
13
|
|
MACV L866-880
|
7
|
2
|
9
|
|
MACV L1491-1505
|
9
|
3
|
12
|
|
MACV L1711-1725
|
8
|
1
|
9
|
|
MACV NP191-205
|
8
|
2
|
10
|
|
MACV Z21-35
|
8
|
2
|
10
|
|
SABV GPC26-40
|
7
|
2
|
9
|
|
SABV GPC436-450
|
5
|
1
|
6
|
|
SABV GPC441-455
|
7
|
1
|
8
|
|
WWAV GPC46-60
|
5
|
1
|
6
|
|
WWAV GPC386-400
|
6
|
2
|
8
|
- a Peptide position within the GPC, L, NP, or Z protein of prototypic strains of GTOV, JUNV, LASV, LCMV, MACV, SABV, and WWAV.
- b Each epitope was tested for binding to 14 common HLA molecules within the DR supertype. The number of HLA molecules bound corresponds to the epitope having an IC50 ≤ 200 nM to the specific HLA molecule.
- c The number of DRB3*0101, DRB4*0101, and DRB5*0101 molecules bound by the arenavirus epitopes with an IC50 ≤ 200 nM.
