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Figure 4 | Immunome Research

Figure 4

From: An integrated approach to epitope analysis I: Dimensional reduction, visualization and prediction of MHC binding using amino acid principal components and regression approaches

Figure 4

Comparisons of different prediction schemes for prediction of MHC-II binding affinity. Comparison of the perfomance of 3 different NN predictors and PLS with the IEDB training set and a random set of 15-mer peptides drawn from the proteome of Staphylococcus aureus COL. The mean estimate of the NN described as Method 2 in the text is used as the base comparator. Comparisons are based on the Pearson correlation coefficient (r) of the predicted ln(ic50) as a metric. The error bar is the standard deviation of the r obtained for the 14 different MHC-II alleles. See Additional File 7; Table S5 for detail.

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