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Table 3 MHC-II binding affinity of heterozygous and homozygous pairs

From: An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics

 

S1

S2

10%tile S1

10%tile S2

10%tile Average

10%tile min of pair

Top Ten

DRB1_0101

DRB1_0101

0.54

0.54

0.54

0.54

 

DRB1_0301

DRB1_0101

3.81

0.54

2.175

0.54

 

DRB1_0401

DRB1_0101

1.95

0.54

1.245

0.54

 

DRB1_0404

DRB1_0101

1.63

0.54

1.085

0.54

 

DRB1_0405

DRB1_0101

1.92

0.54

1.23

0.54

 

DRB1_0701

DRB1_0101

0.62

0.54

0.58

0.54

 

DRB1_0802

DRB1_0101

4.48

0.54

2.51

0.54

 

DRB1_0901

DRB1_0101

2.64

0.54

1.59

0.54

 

DRB1_1101

DRB1_0101

2.35

0.54

1.445

0.54

 

DRB1_1302

DRB1_0101

4.62

0.54

2.58

0.54

Bottom Ten

DRB1_0301

DRB1_0301

3.81

3.81

3.81

3.81

 

DRB1_0802

DRB1_0301

4.48

3.81

4.145

3.81

 

DRB1_1302

DRB1_0301

4.62

3.81

4.215

3.81

 

DRB3_0101

DRB1_0301

5.74

3.81

4.775

3.81

 

DRB1_0802

DRB1_0802

4.48

4.48

4.48

4.48

 

DRB1_1302

DRB1_0802

4.62

4.48

4.55

4.48

 

DRB3_0101

DRB1_0802

5.74

4.48

5.11

4.48

 

DRB1_1302

DRB1_1302

4.62

4.62

4.62

4.62

 

DRB3_0101

DRB1_1302

5.74

4.62

5.18

4.62

 

DRB3_0101

DRB3_0101

5.74

5.74

5.74

5.74

  

Mean

2.92

2.37

2.64

1.88

  

Std Dev

1.47

1.41

1.07

1.08

  1. Ten percentile MHC-II binding affinity statistics for 105 different heterozygous and homozygous supertype combinations for 15-mer peptides from the surface proteome of Staphylococcus aureus COL. The results were obtained using 14 MHC-II supertypes for which training sets were available to train the NN. The surface proteome is defined as proteins that are predicted to have one or more transmembrane helices and are therefore expected to be inserted into the cell membrane. Top and bottom ten pairs are shown in this summary table; complete data set in Additional File 6.