Immunome Research

Table 4 Pearson correlation coefficient of ln(ic50) for pairs of MHC-I and MHC-II alleles.

From: An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics

	MHC-I			MHC-II
Top Ten	HLA 1	HLA 2	r	HLA 1	HLA 2	r
	A*2402	A*2301	0.67	DRB4*0101	DRB1*0404	0.63
	B*4403	B*4402	0.60	DRB1*0701	DRB1*0404	0.63
	A*2403	A*2301	0.54	DRB1*1501	DRB1*0404	0.62
	B*4403	B*4002	0.51	DRB1*0405	DRB1*0404	0.58
	B*4501	B*4403	0.50	DRB1*1101	DRB1*0404	0.55
	A*2403	A*2402	0.49	DRB1*1501	DRB1*0701	0.54
	B*4403	B*1801	0.47	DRB5*0101	DRB1*1101	0.53
	B*4501	B*4002	0.45	DRB4*0101	DRB1*1501	0.52
	B*5301	B*5101	0.41	DRB5*0101	DRB1*0404	0.52
	B*5301	A*2402	0.40	DRB1*1101	DRB1*0802	0.51
Bottom Ten	B*5701	B*1801	-0.26	DRB3*0101	DRB1*0405	0.23
	B*4501	A*2601	-0.26	DRB1*1302	DRB1*0405	0.23
	B*5701	B*5401	-0.27	DRB1*1302	DRB1*1101	0.23
	A*3002	A*2301	-0.28	DRB1*0901	DRB1*0301	0.22
	B*4501	A*6801	-0.29	DRB3*0101	DRB1*0101	0.22
	B*4403	A*3002	-0.29	DRB1*0802	DRB1*0301	0.21
	B*4002	A*6801	-0.31	DRB3*0101	DRB1*1101	0.20
	B*4402	A*2902	-0.31	DRB5*0101	DRB3*0101	0.20
	B*4501	A*2301	-0.32	DRB1*0301	DRB1*0101	0.20
	B*4403	A*2902	-0.34	DRB3*0101	DRB1*0802	0.19
	B*4002	A*3002	-0.46	DRB3*0101	DRB1*0901	0.15

The Pearson correlation coefficients were computed for all allele combinations on a random sample of 1000 15-mers (MHC-II) and 1000 9-mers (MHC-I) from the Staphylococcus aureus COL dataset. All coefficients are significant p < 0.0001. Note that for MHC-I there are both negative and positively correlated pairs. Some of the coefficients ~0.0 were not statistically significant in this case.

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