Bioinformatics analysis of Brucellavaccines and vaccine targets using VIOLIN

Immunome Research

Table 2 Brucella protective antigens verified experimentally.

#	Symbol	Locus tag	Protein Description	Location	References (PMIDs)
1	BLS	CAA86936	Brucella lumazine synthase	Cytoplasm	11953389
2	L7/L12	BRURPL712X	Ribosomal protein L7/L12	Cytoplasm	8873388
3	P39	ABM67295	sugar-binding 39-kDa protein	Periplasm	11447155
4	Bfr	BAB2_0675	Ferritin:Bacterioferritin	Cytoplasm	11447155
5	Bp26	BMEI0536	Periplasmic immunogenic protein	Periplasm	17239499
6	DnaK	BruAb1_2100	Molecular chaperone DnaK	Cytoplasm	17686554
7	IalB	BMEI1584	Invasion protein B	Cytoplasmic membrane	17049676
8	Omp16	BAB1_1707	Outer membrane protein MotY	Outer membrane	18981242
9	Omp19	BAB1_1930	Lipoprotein Omp19	Outer membrane	18981242
10	Omp25	BMEI1249	25 kDa outer-membrane immunogenic protein precursor	Outer membrane	18981242
11	Omp31	BAB1_1639	OmpA-like transmembrane domain	Outer membrane	17014873
12	SodC	BAB2_0535	Cu/Zn superoxide dismutase	Periplasm	15039330
13	SurA	BAB1_0706	Peptidyl-prolyl cis-trans isomerase	Periplasm	17686554
14	Tig	BMEI1069	Trigger factor	Cytoplasm	17239499

Abbreviations: TMH, transmembrane helixes; Adhesin Prob., Adhesin probability; Con-ed represents the conserved proteins among five other genomes from virulent B. abortus strain 9-941, B. melitensis strains 16M and ATCC 23457, and B. suis strains 1330 and ATCC 23445; Host Simil., similarity to human and mouse genomes.