Concept and application of a computational vaccinology workflow

Immunome Research

Table 5 HLA alleles particularly indicated for coverage of ethnicities in selected equatorial African countries.

HLA allele	HLA supertype	# of countries	prevalence	score	Cumulative population coverage
B5802	B58	2	10.3	20.6	12.34
B1503	B27	2	7.4	14.8	22.56
B5301	B07	3	4.9	14.7	31.93
B4901	Unclassified	3	4.6	13.8	35.77
B4201	B07	2	6	12	42.23
B4501	B44	3	3.8	11.4	47.41
B1510	B27	2	4.25	8.5	50.57
B1402	B27	2	3.95	7.9	52.84
B3501	B07	3	2.2	6.6	55.8
B8101	B07	2	2.6	5.2	58.49
B5703	B58	2	2.5	5	59.5
B5801	B58	2	2.3	4.6	64.57
A7401	A03	2	2.1	4.2	66.35
B0702	B07	2	1.9	3.8	68.49
B4101	B44	1	2.7	2.7	69.35
A2301	A24	1	2.5	2.5	70.97

Table 5lists allele data for equatorial Africa as obtained from a publicly accessible allele frequency database. Overall frequencies are biased towards HLA-B alleles. ‘Countries’ indicates the number of countries with a substantial sub-population, ‘Prevalence’ gives the median of allele prevalence in available datasets, ‘Score’ provides the product of Countries and Prevalence, ‘Cumulative Population Coverage’ resembles the cumulative average coverage of populations in Kenya, Uganda and Rwanda by adding individual alleles in order of their rank.