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Table 6 Listing of top-ranked peptides for LMP2A Conservancy Constrained T-cell Epitope Cluster (CCTEC) analysis.

From: Concept and application of a computational vaccinology workflow

start

stop

HLA count

alleles

177

196

5

A2301(1), B3501(2), B7(1), B27(1), A24(1)

178

197

5

A2301(1), B3501(2), B7(1), B27(1), A24(1)

179

198

5

A2301(1), B3501(2), B7(1), B27(1), A24(1)

230

249

5

A2301(1), B3501(1), B7(1), B27(2), A24(1)

236

255

5

A2301(1), B3501(1), B7(1), B27(4), A24(1)

237

256

5

A2301(1), B3501(1), B7(1), B27(4), A24(1)

243

262

5

A2301(1), B3501(1), B27(1), A24(1), B1402(1)

349

368

5

A2301(1), B1402(1), B7(1), B27(2), A24(1)

350

369

5

A2301(1), B1402(2), B7(1), B27(2), A24(1)

351

370

5

A2301(2), B1402(2), B7(1), B27(2), A24(2)

352

371

5

A2301(2), B1402(2), B7(1), B27(2), A24(2)

353

372

5

A2301(2), B1402(2), B7(1), B27(2), A24(2)

354

373

5

A2301(2), B1402(2), B7(1), B27(2), A24(2)

355

374

5

A2301(2), B1402(2), B7(1), B27(2), A24(2)

120

139

4

A2301(1), B3501(1), B7(1), A24(1)

121

140

4

A2301(1), B3501(1), B7(1), A24(1)

122

141

4

A2301(1), B3501(1), B7(1), A24(1)

123

142

4

A2301(1), B3501(1), B7(1), A24(1)

124

143

4

A2301(1), B3501(1), B7(2), A24(1)

125

144

4

A2301(2), B3501(1), B7(2), A24(2)

  1. Table 6 provides the top 20 peptides from conservancy constrained class I T-cell epitope cluster scan ranked by number of covered HLA alleles. ‘Start’ and ‘Stop’ indicate start and stop residues of the proposed region on the alignment and need therefore not be congruent with positions on the reference sequence. ‘HLA count’ indicates how many different class I HLA alleles and supertypes are covered including the alleles HLA-A*2301, HLA-B*3501, HLA-B*1402 and supertypes B7, B27, A24. Numbers in parenthesis indicate how many ligands were identified within the screening window (20 amino acids) per allele/supertype.