An analysis of the epitope knowledge related to Mycobacteria

Immunome Research

Table 5 Number of epitopes that satisfy each of the defined criteria for epitope datasets

Criteria	No. of Unique Epitopes*	No. of B cell Epitopes	No. of T cell Epitopes
All mycobacterial epitopes	1377	357	1114
Ex vivo¹ and standardized assays²	735	344	484
Ex vivo and standardized assays + MHC restriction/defined epitope³	322	182	186
Ex vivo and standardized assays + generalizability⁴	177	67	166

* The number of unique epitopes does not equal the sum of B and T cell epitopes as some epitopes are recognized by both cell types.¹ defined as not needing in vitro restimulation for T cell recognition, and positive binding in all antibody assays.²defined as epitopes assayed by ICS, ELISPOT, and proliferation for T cells responses, and ELISA and antigen competition of antibody binding for B cell responses. ³known MHC restriction and/or defined molecular structures.⁴epitopes have been reported in two different publications or IEDB submissions.