Amino acid biophysical properties in the statistical prediction of peptide-MHC class I binding

Immunome Research

Table 1 Selected Variables for each of the three classifiers using available binding data for MHC Class I allele A*0201

Classifier	Step	Variable Selected	Misclassification error	Gain Achieved
SVM	1	hydrophobicity	0.171839
	2	Volume	0.142022	0.0298169
	3	isoelec	0.125781	0.0162415
	4	branch	0.118570	0.0142109
	5	aromatic	0.118395	0.0001743
Random Forest	1	isoelec	0.136791
	2	Volume	0.130078	0.0067131
	3	hydrophobicity	0.129642	0.0004359
Bagging	1	hydrophobicity	0.146033
	2	Area	0.140279	0.0057541
	3	isoelec	0.137227	0.0030514
	4	aromatic	0.134786	0.0024411