Figure 2
From: Large-scale analysis of human heavy chain V(D)J recombination patterns
Estimation Algorithm Depiction. Flow diagram depicting the steps for estimating the multiple recombination parameters in our statistical model. Rho (ρ) is the parameter for multiple recombination; it represents the probability of a subsequent recombination occurring given that one just occurred and that segments are available for another recombination. Changes to the parameters are accepted stochastically according to the Metropolis-Hastings criterion: with probability 1 if the new chi-square (
) value is lower than the old value (
), or with probability exp(0.5(
)) (37).