Identification of conformational B-cell Epitopes in an antigen from its primary sequence

Immunome Research

Table 5 Overall performance of structure based and CBTOPE algorithms on benchmark dataset

Evaluation parameter	ProMate	PSI-PRED best patch	Patch Dock best model	ClusPro (DOT) best model	CEP	DiscoTope (-7.7)	CBTOPE* (This Study)
Sen*	0.09	0.33	0.43	0.45	0.31	0.42	*0.80*
1-Spe	0.08	0.14	0.11	0.07	0.22	0.21	0.15
PPV	0.10	0.19	0.26	0.39	0.11	0.16	0.31
Acc	0.84	0.82	0.85	0.89	0.74	0.75	0.84
AUC	0.51	0.60	0.66	0.69	0.54	0.60	*0.89*

*(Thr- Threshold, Sen - Sensitivity, Spe - Specificity, Acc - Accuracy, PPV - positive predictive value)